A blog about our discoveries and community

Optimizing my first High Throughput Screen

I, along with Nina, performed our first high-throughput screen – well really medium-throughput but high-throughput for us – on Niemann-Pick Type C (NPC) patient-derived fibroblasts a couple of months back. We wanted to do a pilot screen with the Microsource bioactives...

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NPC1 KO mouse brain study

Well it has been a little while since I wrote a post, and a lot has happened since then, which I am sure you read about in our blogs and tweets. We changed our company name, partnered with Novartis and started partnering with patient groups to engineer our organisms...

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2016 in review

"Last Month in Tweets" was on again, off again in 2016. Apologies, we'll be more consistent with monthly updates across the board in 2017. For now, let's relive the best moments of 2016 at Perlara! Although I wasn't able to announce it publicly for several months, we...

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Perlara’s first preprint

Two weeks ago we posted Perlara's first preprint to bioRxiv, along with all the raw data on GitHub: https://twitter.com/biorxivpreprint/status/796019478999998465 This effort was led entirely by a very talented undergrad named Maria Teresa Chavez, who reached out to...

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Echo 550 acoustic liquid handling technology

High throughput screening (HTS) is essential in the process of finding a potential drug candidate, and automation is key for a good screen both in terms of robustness and efficiency. I kept hearing about the Echo since the day I joined Perlara, but it was only until a...

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