The Niemann-Pick C/Ebola connection

The Niemann-Pick C/Ebola connection

For this post we are going to take a slight detour and talk about something related to Niemann-Pick C, filovirus infection. I am personally interested in the topic because of my love of viruses – plug for the highly informative TWiV (This Week in Virology)...

June in tweets

Last month’s highlight was that we completed the primary screening phase of our NPC lead program. Let’s take a closer look at how summer started at PLab. Prices of orphan drugs for monogenic diseases are skyrocketing while approvals are flat — both...
Why do Purkinje cells die in NPC disease?

Why do Purkinje cells die in NPC disease?

This post is written by Tom Hartl, our resident fly expert. Niemann-Pick C (NPC) is a tragic neurodegenerative disease that is often referred to as childhood Alzheimer’s disease. 95% of patients with NPC carry mutations in the npc1 gene, which codes for the Npc1...
The great orphan drug price debate

The great orphan drug price debate

This post is written by Kiran Singh, Data Guru @PLab. The third and final installment in our series on orphan drugs for monogenic diseases looks into potential causes for the sharp rise in their prices. It’s not readily apparent why this is happening. If we look at...

2015 worm meeting recap

This post is by Sangeetha Iyer, our resident worm expert. This recap is a tad bit late- I’ve been meaning to write about my last conference visit. I was at the 20th International C. elegans meeting held at UCLA from June 24th-28th 2015. Below are the highlights...
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