August in tweets

Coinciding with the end of summer, we wrapped up the hit validation phase of our NPC lead discovery program. In 9 months, we whittled 50,o00 lead-like library compounds down to ~1,000 primary screening hits, which in turn we further winnowed down to ~100 fully...
Detoxing Drosophila

Detoxing Drosophila

Our medicinal chemistry advisor and pharm/tox consultant have asked me, “Do flies have livers?”  I didn’t fully appreciate why they were asking me this until learning more about drug metabolism. In the body, foreign substances, or “xenobiotics,” (pesticides, cleaners,...
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