RNAseq and MOA

RNAseq and MOA

As the cell biology lead at Perlstein Lab, I spend a lot of time thinking about ways to better understand the mechanism of action of the hits from our primary screens. There are many experiments one can do to try to narrow down what pathway their compound is affecting...

October in tweets

Over the summer we completed the hit-to-lead phase of our NPC discovery program, and in the fall we commenced mouse validation studies with PERL101, our most promising hit from the nematode and fly primary screens. First mouse PK data (IV and PO) are in! —...
The value of a Virtual Lab Manager

The value of a Virtual Lab Manager

Back in 2014 when PLab was first funded, one of the first hires wasn’t an employee, but a contractor….HappiLabs. Bootstrapping their way into existence, HappiLabs provides a service called the Virtual Lab Manager, specializing in purchasing lab supplies...
PLab platform white paper

PLab platform white paper

Summary  Perlstein Lab PBC (PLab) is Delaware public benefit corporation accelerating drug discovery for the 5,000+ rare genetic diseases. PLab uses a platform of CRISPR-engineered animals (yeast, nematodes, fruit flies and zebrafish) in phenotypic screens to identify...
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