2015 in review

Feels like the last 12 months went by in a flash! When I wrote this post a year ago, we were just getting started in the lab but we had ambitious plans for the year to come. We set two big goals for 2015. First, to complete a two-species (nematode and fruit fly),...
Phenotypic screens and target ID

Phenotypic screens and target ID

To continue on the theme of understanding your compound of interest’s mechanism of action, let’s discuss target identification (ID). You have just completed your screen and found a hit, but now you want to learn more about why it is a hit. As mentioned before,...
CRISPR genome editing to make an NGLY1 fly

CRISPR genome editing to make an NGLY1 fly

N-glycanase 1 deficiency, or “NGLY1,” is a rare genetic disorder arising from mutations in the ngly1 gene.  The disease was recently diagnosed in what was a remarkable partnering of patient advocates and scientists who used DNA sequencing to trace the disease-causing...
Translate »