A yeast model of cystic fibrosis

A yeast model of cystic fibrosis

At PLab we’re always on the lookout for new publications describing simple animal models of rare genetic diseases. The more non-obvious the model/disease fit appears at first blush, the more exciting are any results that confirm therapeutic relevance in humans...
Autophagic flux and NPC

Autophagic flux and NPC

It has been a while since you have heard from me. We are deep in post screen characterization of our NPC hits so I thought I would take a step back to the beginning to discuss NPC disease biology. We focused a bit on the cholesterol and lipid metabolism aspects of...

April in tweets

We kicked off April with Tamy’s first post on the PLab blog. She and Tom have been working hard to launch our Drosophila NGLY1 HTS campaign. Tamy describes an unexpected challenge we encountered during assay development. DMSO and Drug Discovery...
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