A secondary assay for worms

A secondary assay for worms

We’ve not had a worm post in awhile, but that doesn’t mean that worms (and we) haven’t been busy. We’ve been optimizing and conducting a secondary assay on them to determine if the npc disease pathology can be resolved by testing the hits that...
A vision for Perlstein Lab

A vision for Perlstein Lab

Today’s post will focus on the vision for PLab. Let’s start with a basic statistical concept- long tail distribution. While this form of frequency distribution has been around since the 1940’s, it gained prominence in fields outside of insurance and...
Mouse models of NPC

Mouse models of NPC

Now that we’ve completed our screen in all of our invertebrate models of Niemann Pick Type C (NPC) disease, it’s time for us to switch gears to the higher models of NPC. We are in the process of moving our validated screen hits for additional testing in a...
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