Category: NGLY1

New NGLY1 Preprint

New NGLY1 Preprint

What the NGLY1 community can learn from the humble fly On the first day of the new year, we submitted a new NGLY1 model preprint entitled “Defects in the neuroendocrine axis cause global developmental delay in a Drosophila model of NGLY1 Deficiency.” Follow on...
Fly models of NGLY1 Deficiency

Fly models of NGLY1 Deficiency

Comparative fly model studies of NGLY1 Deficiency Earlier this week I was alerted on Twitter (where else?) to a new NGLY1 paper from Dr. Clement Chow’s lab at the University of Utah entitled: “Transcriptome and functional analysis in a Drosophila model of NGLY1...
Fruit Flies and DMSO Sensitivity

Fruit Flies and DMSO Sensitivity

On my last blog I told you guys about a good friend of small drugs, DMSO who has wonderful characteristics that make it such an irresistible small drug solvent. Although is a great friend of small drugs, some other of its characteristics make DMSO a toxic molecule to...
CRISPR genome editing to make an NGLY1 fly

CRISPR genome editing to make an NGLY1 fly

N-glycanase 1 deficiency, or “NGLY1,” is a rare genetic disorder arising from mutations in the ngly1 gene.  The disease was recently diagnosed in what was a remarkable partnering of patient advocates and scientists who used DNA sequencing to trace the disease-causing...
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